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Additionally, pharmacokinetics, biodistribution, and clearance route are studied after intravenous injection in a mouse model, reflecting their overall safety.
Antibody engineering enables modification of key properties (immunogenicity, valency, biological inertness, pharmacokinetics, clearance route, site-specific conjugation) in order to produce targeting agents optimized for molecular imaging.
Furthermore, biodistribution studies through optical imaging (OI) and the use of radiolabelled polymer-drug conjugates demonstrated conjugate safety profile and renal clearance route of the selected PGA-doxy candidate, settling the adequacy of our conjugate for future in vivo evaluation.
Since the Newburyport/Rockport line was no longer a freight clearance route past the General Electric plant in West Lynn, a full-length high-level platform was selected.
High activity in the bladder suggested the clearance route of this agent.
This has implications ranging from the potential for infusion-related reactions to the ultimate clearance route and toxicity.
Similar(47)
Delivery and clearance routes of the contrast agents are also important factors.
Larger nanoparticles can provide higher contrast images but can present difficulties during delivery and clearance routes.
The metabolic fate of the nanoparticle and the single and multiple dose toxicity must be investigated, along with many other factors such as clearance routes.
The two main clearance routes of organelles and proteins in eukaryotic cells are the ubiquitin-proteasome system (UPS) together with heat shock response and the autophagy-lysosomal pathway.
This implies that in the presence of limiting rM numbers, PMNs can be efficiently cleared leading to resolution, with lymphatic drainage or phagocytosis by stromal cells representing likely alternative clearance routes for PMNs under these conditions.
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