Sentence examples for clearance pathway for from inspiring English sources

The main clearance pathway for organelle turnover in cells is the autophagic pathway.

Because only the parent compound binds to the estrogen receptor, conjugation is a detoxification mechanism that represents the major clearance pathway for BPA.

Our hypothesis was that if the CSF was not an important clearance pathway for Aβ removal from the brain, then the accumulation of Aβ would be the same between hydrocephalic and control tgAPP21 rats.

If the TP is a cytokine or modulates a cytokine which can effect regulation of various CYPs, and these CYPs provide the primary clearance pathway for the co-administered SMD, then a clinical DI study to examine potential interaction should be considered.

In the present study, the addition of a direct clearance pathway for S-ketamine from its central compartment beside conversion to S-norketamine improved the model fit for both compounds, supporting the rapid elimination of S-ketamine unchanged in urine, as already largely documented in equine and in other species for ketamine [ 18, 30].

In the absence of a true lymphatic system in the brain parenchyma, alternative clearance pathways for excess fluid and waste products have been proposed.

Consistent with this hypothesis, Ferin and Oberdörster (1992), based on results from a rat inhalation study with ultrafine (< 100 nm) titanium dioxide (TiO2), reported histologic evidence for the existence of two distinct clearance pathways for particles in the peripheral lung via a) airways and (b) the interstitial lymphatics and back to the airways, and that these are interconnected.

The impact of HI on the multiple enzymes involved and involvement of alternate clearance pathways for cinacalcet (fm,CYP3A4 = 0.51) may contribute to the observed unusual DDI-OI profile, where severe HI caused larger AUCR than DDI with ketoconazole (4.25 vs. 2.03).

In neurons, it is involved in cellular homeostasis and cellular protein clearance pathway and for the remodeling of terminals in support of neuronal plasticity [ 38].

Different developmental patterns for the various clearance pathways of paracetamol result in continuous changes in the relative contribution of each pathway to the overall paracetamol clearance as well as in changes in total paracetamol clearance.

Renal clearance pathway as seen for urea-based peptidomimetic PSMA inhibitor [18F]DCFPyL was also reported for 18F-labeled phosphoramidate peptidomimetic as small-molecule PSMA-imaging agent in LNCaP- and PC3-bearing mice [18].