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Complete clearance of warts and no recurrence thereafter.
Because the object of treatment is clearance of warts without recurrence, this outcome was sought.
Complete clearance of warts was reported in all five trials of HIV negative patients.
The rate of natural clearance of warts from initial infection is not clear.
The main outcomes sought were the number of patients with: Complete clearance of warts present at the start of treatment.
In three trials complete clearance of warts at the end of treatment plus no recurrence occurred in 37% of patients treated with imiquimod 5% cream and 4% of those treated with placebo.
Similar(53)
One was the number of new warts that appeared after treatment started, and the clearance of these warts during treatment; clearly this could not be done on an intention-to-treat basis.
Conclusions Salicylic acid and the cryotherapy were equally effective for clearance of plantar warts.
The time to clearance of plantar warts was derived as the number of days from randomisation until the date of clearance, as detailed from the participant's self reported questionnaire.
If we add our trial data into a meta-analysis, we find the odds ratio for cure is 1.07 (95% confidence interval 0.63 to 1.79), indicating that the odds of clearance of plantar warts is similar with either treatment.
A Cox proportional hazards model was used to compare the time to clearance of plantar warts between the two groups adjusting for the same covariates as for the primary outcome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com