Studies in rodent systems have demonstrated the role of astrocytes in glutamate clearance, expression of key astrocyte-specific proteins and the ability to modulate the synaptic maturation of co-cultured neurons.
However, it is important to consider that because CPFA cannot remove LPS from the circulation [ 37] because of the features of the sorbet cartridge, we hypothesized that the beneficial effects in our model might be due to the clearance of another key mediator of LPS signaling.
The focus of this study was insulin clearance, a key determinant of fasting and postprandial plasma insulin levels, which is known to be reduced in obesity particularly when features of the metabolic syndrome are present [ 5].
Clearance of apoptotic cells is of key importance during development, tissue homeostasis and wound healing in multi-cellular animals.
The size, shape, surface area, number, and clearance of GNPs play a key role in toxicity and accumulation in the different rat organs.
The size, shape, surface area, number, and clearance of GNPs play a key role in toxicity, and the distribution and accumulation of GNPs in the different rat organs may be mediated by dynamic protein binding and exchange.
Capillary clearance of glucose is a key factor affecting net intestinal glucose absorption at the intestinal border, as submucosal capillary glucose concentration rapidly equilibrates with that in the interstitial solution.
Importantly, we provide here full pharmacokinetic analyses allowing an evaluation of key pharmacokinetic parameters (clearance, half-life).
While clearance of S. pyogenes is the key determinant of treatment efficacy, co-infection with S. aureus warrants consideration of treatment options that are effective against both pathogens where impetigo is severe and prevalent.
Both the volume of distribution and clearance are the key determinants of the pharmacokinetics of a drug.
