For both MRSA and VRE analyses, we collected information about the total sample size and number or percentage of subjects with documented clearance of colonization and the corresponding time after documented colonization at which the assessment of clearance was made for each included study.
The lack of a phenotype despite the reduced numbers of T cells in the periphery of DG/Lck-cre mice is compatible with earlier studies that documented clearance of LCMV infection requires ∼350,000 virus specific CD8+ and 7,000 CD4+ T cells [30] and that diminished thymic input of T cells has a minimal impact on the control of LCMV infection [31].
Approximately six weeks after admission, there was documented clearance of MSSA from her blood.
Given currently available assays, documented clearance of colonization may in fact represent a level of colonization below the limits of detection (with the same strain or different strain).
We found that documented clearance of candidaemia during the early period of antifungal therapy was deferred in patients with concurrent bacteraemia.
We performed parallel searches in OVID Medline for studies that reported the time to documented clearance of MRSA and VRE colonization in the absence of treatment, published between January 1990 and July 2012.
At 10, 20, 30 and 40 weeks after initial determination of VRE colonization, the model estimated that 19, 38, 61, and 80% of subjects had documented clearance of colonization, respectively.
The clinical outcomes of cases and controls are shown in Table 3. Within 3 days after initiation of antifungal therapy, documented clearance of candidaemia was significantly infrequent in cases (p = 0.035; Table 3).
At one, two, three and four years after initial determination of MRSA colonization, the model-estimated proportions of subjects with documented clearance of colonization were 41, 54, 66, and 77%, respectively.
Moreover, the date of the first negative blood culture is important, because the recommended length of treatment is 14 days after the documented clearance of Candida from the bloodstream and resolution of symptoms attributable to candidemia.
