Sentence examples for clearance of compounds from inspiring English sources

Obesity is also associated with increased clearance of compounds metabolized by CYP2D6 (Brill et al. 2012).

This value is 1% of the total L-Glu elimination from the CSF, and extremely low compared with the estimated efflux clearance of compounds, such as benzylpenicillin and PGE2, which shows facilitative elimination via the transporters at the BCSFB [ 6, 47, 48].

In vitro testing strategies have been applied successfully to predict the in vivo pharmacokinetics and clearance of compounds for years, including the potential of compounds to be involved in significant adverse interactions through the induction or inhibition of liver enzymes (Lin, 2006 Hewittt et al., 2007a; Obach, 2009; Obach et al., 2008).

Although the overall metabolic capacity of LSEC is less than that of hepatocytes (∼1/10*), their overall role in hepatic clearance of compounds and hepatoxic events has been generally overlooked and underappreciated (Schrenk et al., 1991; Sacerdoti et al., 2003; Wu et al., 2008).

The glymphatic hypothesis, with perivascular flow into and out of the brain and astrocytic aquaporin-4 linked flow within the brain [ 8– 11], continues to generate important data on the clearance of compounds from the brain in disease (e.g. [ 12, 13]) as well as the effects of parameters such as sleep and posture on such flow [ 14, 15].

However, the clearance of compound 53 in liver microsomal tests was moderate to high, and the solubility of compound 53 was suboptimal.

We focused on systemic clearance of parent compounds in rats, and performed in vivo pharmacokinetic screening.

The liver is critical in multiple processes, including the clearance of endogenous compounds, in the synthesis of macromolecules, and in organ-specific biotransformation processes.

An induction of CYPs via AHR signaling is to enhance clearance of these compounds.

Furthermore, lower levels of testicular steroids in immunocastrates accelerate the metabolic clearance of indolic compounds [ 13].

Another limitation is the rapid metabolism and clearance of many compounds of concern.