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We speculate that the detection of viral variants with altered amino acids in CTL epitopes implies the successful clearance of cells harboring wild-type virus.
Differences in the rapid clearance of cells from the blood may reflect the number of B16F10 cells available for lung colonization in RNF13-KO mice.
OBJECTIVE: A recent analysis suggested that ovarian cancer risk increased with time since last birth, possibly because of some aspect of pregnancy that affects the clearance of cells that have undergone malignant transformation.
Fibronectin increases apoptotic clearance of cells coated e.g. with C1Qs, both molecules being up-regulated here.
2) CD14 is a major receptor involved in the nonphlogistic clearance of cells undergoing apoptosis [13] and its overexpression in the brain may reflect the well-documented increase in endothelial and neuronal apoptotic cells during ECM [6], [14], [15].
For example, studies of gemcitabine-induced apoptosis of jejunal crypt cells indicate that apoptosis resolves by 24 36 hours post-treatment [39] perhaps because, in contrast to the apparently inefficient clearance of cells in malignant tissues, phagocytosis of apoptotic cells is efficient in normal tissues [40].
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Singleton A, Khong D, Chin LY, Mukundan S, Li M, Parekkadan B. An engineered biomarker system to monitor and modulate immune clearance of cell therapies.
Because of the inherent biological differences in MSC by donor, and where applicable, their manufacturing and delivery processes, defining such doses by indication is a major obstacle for obtaining regulatory clearance of cell products classified as a drug.
These cell corpses persisted much longer than the cell corpses resulting from physiological cell death (Fig. 2L), suggesting that HEC-23-induced lysosome damage also compromised the clearance of cell corpses.
Inappropriate clearance of cell corpses may lead to autoimmune diseases and chronic inflammation [18].
Although there was a clear role for neutrophils and eosinophils for the clearance of cell corpses in the thymus during acute cell death, we did not observe quantifiable differences in cell clearance at steady state.
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