Sentence examples for clear uncoupling from inspiring English sources

We also observe clear uncoupling between mutation-driven changes in function and binding affinity.

Thus while the remaining RML prion infectivity appears to be roughly proportional to the concentration of PK-resistant PrP, there is a clear uncoupling of disease-related PrP concentration and prion infectivity in thermolysin-digested samples.

Remarkably, the mutant and the wild-type had similar temperature optima and activities at their temperature optima, thus providing a clear case of uncoupling of thermal stability and thermoactivity.

Although it is not clear how mild mitochondrial uncoupling can influence TGF-β signalling, it is known that this cytokine can induce the release of mitochondrial calcium stores and that this process is necessary for the activation of protein kinases and downstream signalling of TGF-β [ 34].

However, it was not clear whether NOS was uncoupled or whether generated NO was scavenged; both mechanisms appear likely.

The reason for the increased longevity of mice with skeletal muscle uncoupling is not yet clear.

It is not clear which alterations cause this apparent uncoupling in daf-2 mutants.

Thus, given the prevalence and emerging signalling importance of ADAMs in breast cancer, ADAM-mediated ligand shedding may provide interesting new avenues for therapeutic exploitation to abrogate EGFR signalling, particularly since it is now clear that EGFR inhibition has considerable potential to uncouple diverse mitogenic inputs.

In all, these findings strongly suggest that chronic muscle-restricted mitochondrial uncoupling is able to induce a mild but clear motor neuron pathology, likely as a result of the progressive degenerative process initiated at the NMJ.

Another clear advantage of the approach presented here was the strict uncoupling of solventogenesis and sporulation which allows the identification of candidate proteins distinctly related to the metabolic shift.

The role of neurovascular and gliovascular uncoupling in modulating brain endothelial properties during cerebral ischemia is not clear.