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Riboswitches that regulate gene expression at the transcriptional level are an ideal system for investigating this aspect of RNA folding as ligand-dependent termination is obligatorily co-transcriptional, providing a clear readout of the folding outcome.
Importantly, the study is not a de-novo genetic or viral study, rather the combined application of well established knowledge that should result in a clear readout in small sets of individuals.
We next analyzed the ability of FAM150A or FAM150B to activate human ALK in a Drosophila model, which offers a clear readout.
They may provide more value in understanding the biology of the peripheral biomarker(s) in relation to brain pathology than in defining a clear readout of risk.
Implications and future directions This work provides a new animal model of ALS and a robust assay with a clear readout that together have the potential for use in high-throughput drug screening.
Dial gauges are more accurate, giving you a very clear readout of your tire's pressure.
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The phosphorylation of ACC provides a more clearer readout of AMPK activation than the phosphorylation of AMPK39.
An attacking army could slip past enemy lines on the ground as early warning systems give false all-clear readouts to defenders.
A vacuum fluorescent display (VFD) option gives a clear bright readout in temperatures down to-40°C and in full sunshine.
The ability to detect a clear phenotypic readout that could distinguish between BRAFWT and BRAF disease alleles, allowed us to use the zebrafish as the basis for further investigation of the CFC-pathway allele function.
The investigations presented in this study intentionally focussed on known model proteins being critical for TCR-mediated signaling events during T cell activation in order to have a clear phenotypic readout, e.g. reduced cytokine secretion, in the silenced cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com