Sentence examples for clear rationale of from inspiring English sources

Therapeutic application of PIs in an autoimmune disease setting is much less explored, despite a clear rationale of (immuno) proteasome involvement in (auto antigen presentation, and PIs harboring the capacity to inhibit the activation of nuclear factor-κB and suppress the release of pro-inflammatory cytokines such as tumor necrosis factor alpha and interleukin-6.

Most damning is the commission's statement that it will have trouble interpreting this catch-all law because there is no "clear rationale for many of the changes".

However, there was no clear rationale for choosing which of the infinite number of combinations of changes in afforestation rate and gross forest loss rate that could be used to satisfy a fixed 20% reduction in net loss rate.

1) The authors have to provide a clear rationale for their selection of DNMT3b only (instead of DNMT3a or both) to study de novo DNA methylation, since DNMT3a has been shown to have stronger enzymatic activity than DNMT3b in (Baubec et al. 2015), and DNMT3a (but not DNMT3b) is frequently mutated in tumors.

Moreover, data from several single-agent chemoradiation studies provide a clear rationale for a simplification of chemoradiotherapy by the replacement of infusional 5-FU with the oral prodrug capecitabine (Xeloda, Hoffmann-La Roche Inc., Basel, Switzerland) (reviewed by Glynne-Jones et al, 2006).

As the majority of MCL express CD20, there is a clear rationale for the use of rituximab in this setting.

In the absence of a clear rationale to justify the evolutionary retention of a death only pathway, we hypothesize that yca1 also influences non-apoptotic events.

Moreover, a design model is proposed to provide a clear rationale for the effects of transverse-steel on the shear contribution of FRP.

The results of the studies described above have provided a clear rationale for the use of drugs targeting HER2, such as trastuzumab, to treat gastric cancer.

This analysis did not provide a clear rationale for the inactivity of the benzene γ-turn scaffolds.

In 5 20% of cases, this can be attributed to aberrant c-Met activity, providing a clear rationale for the use of c-Met inhibitors in these patients.