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In both Rhizobiales and Enterobacteriales, a clear essentiality was observed for chromosomal syntenic genes, agreeing with their sequence restrictions for change.
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If the gene expression data are grouped by essentiality it becomes clear, that essential genes show a significant increased proportion of highly expressed genes.
However, the function of this gene is not well understood and it is not clear how it suppresses the essentiality of rpoE.
The case of pantothenate, the only essential vitamin with a clear metabolic effect is unique, as its essentiality is strain-dependant.
The explanation for the presence of orthologs in these organisms being the most predictive of essentiality in E. coli is clear when considering their evolutionary history and lifestyle.
Selecting features associated with gene essentiality is fundamental to predict essential genes in feature-based models.
The essentiality of YopJ/P functions for Yersinia virulence in vivo is not yet clear.
Thus, there is a clear relationship between connectivity of genes, in these weighted gene co-expression networks, and gene essentiality across the whole network.
Only very recently, Yu et al. [ 28] have presented clear evidence for a high-quality binary interaction network, constructed from Y2H data, that protein connectivity does not correlate with essentiality and argue that this discrepancy with earlier findings originates from biases towards essential and well-studied proteins in the original datasets used in those studies.
Therefore, the essentiality of CBF1 in cell survival has been changed during the evolution of aerobic fermentation, but it was not clear about the cause of lethality.
There is a notion of museum essentiality that is by no means beyond debate".
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