If we think of this as a genetic screen for mutations causing a specific phenotype, with demonstrated saturation mutagenesis of the human population [ 32], then the most effective approach to follow up these discoveries is clear: find the mutations of largest effect and use these as entry points to elucidate the underlying biology.
However, Hollinger made it clear that Discovery has been out of the frame for an extended period of time now.
The development of G protein-biased agonists for the μ-opioid receptor (MOR) offers a clear drug discovery rationale for improved analgesia and reduced side-effects of opiate pharmacotherapy.
He said he "wouldn't know" about any such deal and Malone runs "a clear distinction" beween Discovery and Virgin.
For a reality check today, take the state of science, which demands high levels of brainwork and is measured by clear benchmarks of discovery.
Judge Thomas R. Fitzgerald, the chairman of the court's committee, said today in an interview that "the attempt to have a clear rule concerning discovery in DNA matters was significant".
As Mitt Romney's Op-Ed this morning indicates, the Republican Party has made its first clear post-election discovery: it can unite traditional conservatives of the George Will type with populist conservatives of Palin-plumber constituencies by running hard against big government, bailouts of all kinds, and Wall Street.
He didn't shoot the movie strictly in sequence (though he wanted to do so), so it's not clear whether this discovery coincides with the film's chronology, but he did film the island scenes first (and arduously), and it's as if the formula that he discovered in the wild found its definitive application upon his return to urban life.
It is clear that service discovery is a critical issue for infrastructure that aims to support the emerging care environment.
Yet it is also clear that a discovery might come about in the course of normal science and initiate a 'revolution' (in a non-Kuhnian sense) in a field because of the unexpected insight it provides and the way it opens up opportunities for new avenues of research.
