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Archaeological excavations of pre-Catholic cemeteries in Nousiainen and surrounding parishes show a clear discontinuation of traditions in the early 13th century, but no abrupt changes are apparent in the religious environment among the 12th century finds.
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In fact, when the indication is less clear-cut, discontinuation may be less likely to occur.
However, it is not clear whether discontinuation of the original antipsychotic treatment or the switch to clozapine leads to improvements in movement symptoms.
Thus, there was no added benefit to continuing treatment once patients had responded and the optimal duration of treatment is 12 to 24 weeks, with discontinuation upon "clear" or "almost clear" hands.
For later asymptomatic transaminitis, the approach is less clear, but many experts recommend discontinuation of nevirapine if ALT is greater than 5 10 times the upper limit of normality.
The response was short-lived, with clear progression in October 2012, followed by discontinuation of vemurafenib.
However, there are no clear recommendations on the monitoring and discontinuation of SUP in critical ill patients to date, and this needs to be addressed in future investigations.
It's a practice usually reserved for clearing out inventory prior to product discontinuation.
It is not clear why there is this difference in discontinuation between the two countries: baseline demographics were similar in the two cohorts.
The impact of switching and discontinuation of medication is not clear as the limited literature to date has been based on selected clinical samples of pregnant women with bipolar disorder in whom discontinuation of mood stabilisers was associated with a marked increased risk of relapse during pregnancy after adjusting for potential confounders [ 9].
No clear difference was seen for the outcome discontinuation or modification of treatment due to adverse effects (RR 1.46, 95% CI 0.83 to 2.58; 2 trials, 317 women; Analysis 3.2).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com