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A second limitation is that participants in PHYLLIS were hypertensive and received antihypertensive drugs capable of causing a clear cut reduction in ambulatory and clinic measured blood pressure.
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Whereas the 1992 Rio conference agreement was a soft law, the Kyoto Protocol was a hard law, with clear-cut reduction targets of greenhouse gas emissions for regions and countries.
In our model system, PML Ib caused a 10 fold reduction in viral titer as well as a clear-cut reduction in the accumulation of viral proteins representative of both immediate early and late times in infection.
Hence, it is not possible to deduce the level of surface expressed channels from the immunostaining intensity, although there was a trend consistent with reduced expression of L860P (3 out of 7 experiments showed a clear-cut reduction).
46 Despite the lack of randomization in this study, a clear-cut reduction in the LUTIs and bladder discomfort associated with pelvic irradiation was observed, with statistically significant differences in terms of dysuria, nocturia, and urinary frequency.
An objective response (OR) was defined as one that requires improvement in the Medical Research Council neurological status (Table 3 >) by one grade as well as a clear-cut reduction in mass effect on CT or MRI assessment with a minimum duration of 4 weeks.
Brain histopathology from these deceased subjects demonstrated clear-cut reductions in brain parenchyma Aβ (Nicoll et al 2003; Ferrer et al 2004; Masliah et al 2005).
Although plasma cAMP concentrations tended to increase during the HD AM5 infusion in the present study, levels did not rise significantly above control, and the LD infusion period was characterized by clear-cut reductions in cAMP.
Clear-cuts with reduction in AGB and C stocks are visible as red areas, while forest growth representing increases in AGB and C is visible in green.
This overall effect does suggest an overall reduction in histopathological features in female compared to male Premutation carriers, but not a clear cut one.
Our results are clear cut.
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