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Difficulties in clinical management (e.g. treatment and prognosis) are related to the complex identity of gliomas, which lack reliable morphological and molecular signatures, precluding thus the establishment of a clear cut classification discriminating between different tumor subtypes [ 12].
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Furthermore, a recent case report investigated, using f-MRI, a 68-year-old patient suffering from excruciating trigeminal autonomic headache attacks, in whom frequency, duration and therapeutic response allowed no clear-cut classification as one of the subtypes of TAC [91].
For this reason, critics have found clear-cut classification of Crane's work problematic.
Biomarkers attract a clear-cut classification where there is corroborative evidence.
The mixed prokaryotic eukaryotic branching pattern of the remaining 49 (6.9%) trees did not enable a clear cut rooting and classification of the trees into one of the above categories (fig. 1 d ).
However, this histological classification is not clear cut.
There just is no clear cut way to map our social classifications of race onto a meaningful biological category.
However, the issue isn't so clear cut, and many trans rights advocates are concerned this classification will add the additional stigma of disability to an already very marginalized population.
The classification of benign from malignant ACTs is not clear cut and is the subject of much debate.
These are related to immune cells (B cells, lymphocytes; neutrophils), anaemia (red blood cell count and linked measurements) and inflammation (magnesium, neutrophils), and their classification as pro-longevity or antilongevity (neutrophils only) is clear cut.
Sometimes it's less clear cut.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com