However, a clear causative role for hyperglycaemia has not been established.
We propose that for those risk alleles without clear causative polymorphism due to broad linkage disequilibrium, hypothesis-driven lineage-focused epigenomic QTL studies may be an alternative for gaining increased resolution of disease causing polymorphisms.
While our study design precludes us from asserting a clear causative link the findings nonetheless suggest that this type of health service provision may represent a feasible option to improve primary/secondary integration and improve overall TIA management and stroke prevention especially.
Patients with a clear cause for their urticaria, who were mostly acute urticaria patients, were advised to avoid the causative agent, i.e. the suspected food or drug.
This preliminary work's importance is further emphasized by the fact that specific markers were identified in an outbred human population with genetic variability, no clear common causative agent, and simply a shared clinical syndrome.
However, explanatory solutions for mixed slip-systems are non-unique at the scale of the EBSD data, which prohibits the clear identification of causative slip systems and their relative contribution.
It is not clear if this causative link between expression site silencing and progression through the life cycle also occurs in a natural infection.
Regarding the specific clinical features of the disease, it is clear that the causative pathogen leads to miscarriages or stillbirths ("a blight on wives in travail," lines 26 27, meaning women give birth to dead babies) (2, 3 ).
Although previous studies [ 11- 13] demonstrated a clear, and likely causative, correlation between the QA-ratio of RUNX2 and face length in carnivorans, our analyses, controlling for phylogeny, evolutionary rates, and divergence times, show that the RUNX2 QA ratio is not generally correlated with facial length across placental mammals.
Although early and acute high viral load and severe CD4+ T cell depletion are associated with a poor long-term outcome, it is not clear that this is causative: if animals vary in their susceptibility to infection, then highly susceptible animals would be expected to have highly depleted CD4+ T cells and high viral loads in both the acute and chronic phases of infection.
Most studies have assigned an important role of vaspin in the development of obesity and MetS, but it is not clear whether it has causative or protective effect in these conditions.
