In the study of prion disease, it was found that during different stages of the disease, different regions of the network were activated and they formed a clear disease aggravation pattern on the network [ 2].
Ensuring that there are clear definitions of recurrence, aggravation and exacerbation, as are provided by the SIC model, would help in identifying if the injuries were new index injuries.
Although there are no clear diagnostic criteria for TMJ dysfunction, aggravation of pain by manipulation or function of the jaw is a cardinal sign.
In any case, it's clear Mr. Heller does not need the aggravation.
Risk factors from physical, psychological, and social domains have been identified, but the relative contribution of the various risk factors to the onset and aggravation of UEMSDs is not clear.
While part of that frustration will always be present when working on high-risk projects, a lot of the aggravation comes from the lack of clear signposts that allow founders to judge their company's performance.
Current data are "insufficient to reach any final conclusions on all effects of the three-hour rule," the agency said, adding: "One thing, however, is absolutely clear — tarmac delays in excess of three hours and the aggravation, stress and hardship they have caused have virtually disappeared".
They have generated some marketing buzz, but due to May's aggravation of an abdominal injury, it's not clear if she can play.
Her PA who was nothing but aggravation... regenerating aggravation... becoming more and more aggravating as she grew older.
