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Classifying treatment based on the WHI current medication inventory collected at baseline would not capture these treatment changes.
However, criteria such as RECIST reduce the information by classifying treatment effect into only four categories (complete response, partial response, stable disease and progressive disease).
Another limitation was that our method of classifying treatment status could have resulted in misclassification bias if some patients who had received antiretroviral therapy were included in the analysis.
The clinical anchors (CGI-I, CGI-S, and PSS-I for classifying treatment response status) used in our analysis were most appropriate as they were highly clinically relevant and strongly correlated with the HRQOL health-utility EQ-5D and QWB-SA.
Such models have been successfully applied in distinct gene expression time course applications such as querying (Schliep et al., 2003), model-based clustering (Costa et al., 2005; Schliep et al., 2005) and classifying treatment responses (Costa et al., 2009; Hafemeister et al., 2011).
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Despite the challenges encountered in classifying treatments as strategic or ineffective, their inclusion in this study was important as they were evident throughout the five year period.
The most frequent reasons for classifying treatments as inadequate were inadequacy of treatment duration (48.8%) and lack of adequate dosage adjustment in patients with chronic renal or hepatic insufficiency (33.8%).
"Mixed" headaches have characteristics of both types, and because they're hard to classify, treatment can be challenging.
We sought to determine molecular correlates of the treatment response to IFNβ therapy in relapsing-remitting MS. Response to IFNβ was defined in advance, using MRI to classify treatment response in individual patients.
The primary outcome used to classify treatment success or failures will be a 5-point global assessment of change.
A pediatric medical resident abstracted data from patient records, and a pediatric oncologist classified treatment into one of four groups.
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