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Boyden's lab is also interested in using this technology to trace the connections between neurons and to classify different subtypes of neurons based on which genes they are expressing.
PLSR is used for 3-D data visualization, and SSL is used to classify different subtypes of breast lesions.
This study followed an in silico strategy to first compile a largest possible list of miRNA targets predicted by multiple algorithms, which was subsequently filtered by GO terms and their enriched representation, and their ability to classify different subtypes of lung cancer.
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Of these, 36/75 were re-classified as different subtypes of osteosarcoma, 15/75 as conventional, 13/75 as telangiectatic, 6/75 as high-grade surface osteosarcoma and 5/75 were ineligible.
Some of the 51 cell lines with the correct origins were further classified into different subtypes of cancer or different stages in cancer development based on supervised learning methods.
Previously, large-scale gene expression profiling using RNA extracted from tumor tissue has demonstrated its utility in classifying different tumor subtypes of leukemia and lymphoma [ 33, 34] and solid tumors [ 35, 36].
There are currently 13 different subtypes of OFD, classified by subtleties of phenotypic presentation.
Taking advantage of available clinical information of primary tumor samples used to generate gene expression profiling data, we further classified those cell lines with the correct origins into different subtypes of cancer or different stages in cancer development.
Nevertheless, our results suggest that specific molecular expression patterns, in addition to others previously defined for myositis, might provide insight into classifying and understanding the pathophysiology of these different subtypes of myositis.
For example, classifying blood from brain is a relatively easy problem, but discriminating among different subtypes of blood is a much harder one.
Currently, there are four different subtypes of colorectal cancer, although many other subtypes have been proposed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com