In contrast, PC upregulated the expression of many genes classified in skeletal development, including collagen type II alpha1, fibroblast growth factor receptor 3 (FGFR3), and SRY- (sex determining region Y-) box 9 (SOX-9).
In contrast, the expressions of many genes classified in skeletal development, steroid biosynthetic process, and DNA repair were upregulated by PC.
PC upregulated the expressions of many genes classified in skeletal development, including putative chondroprotective proteins FGFR3 and SOX-9 [ 48, 49].
As shown in Table 3, of the 26 differentially-expressed genes classified in skeletal development, the expressions of 17 genes, including collagen type II, alpha 1 (COL21.2921.29 fold change), collagen type XI, alpha 1 (COL11A1, 9.86 fold change), aggrecan (ACAN, 9.17 fold change), FGFR3 (2.40 fold change), FGF18 (2.33 fold change), and SOX-9 (2.00 fold change) genes, were upregulated by PC.
Of the 28 differentially expressed genes classified in skeletal development, the expression of 18 genes, including annexin A2 (2.17-fold change), vitamin D (1,25- dihydroxyvitamin D3) receptor (VDR; 2.11-fold change), aggrecan (ACAN; 1.80-fold change), collagen type 1, alpha-1 (COL1A1; 1.66-fold change), and collagen type XI alpha-1 (COL11A1; 1.50-fold change), wandupregulated by Pcollagen 2).
For example, of the 25 differentially expressed genes classified in muscle tissue development, the expression of 15 genes, including insulin-like growth factor binding protein 5 (IGFBP5; 8.57-fold change), was upregulated by PC.
FGFR3 and SOX-9 were two genes classified in the skeletal development.
Some annotated transcripts such as matrix metalloproteinase 1, metalloproteinase inhibitor 2, and metalloproteinase inhibitor 3, were classified in the organism development GO subcategory.
Since these devices are still classified as in development, it is quite possible that the feature-sets may change — even dramatically — before they are released to the public.
Mouzas are classified in four stages of development as High level, High middle level, Low middle level and Low level.
