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For classification of subtypes E2A-PBX1, MDR and C4.5 both have an AUC of 100%.
Classification of subtypes of dementia would have increased understanding of possible pathological mechanisms behind our findings.
Biomarkers were chosen for known prognostic, and in some cases predictive, effect and relevance to biologic classification of subtypes.
Classification of subtypes was performed using the aCGH BRCA1-like classifier developed by Joosse et al (2009).
Classification of subtypes of VWD is mandatory, as desmopressin therapy causes thrombocytopenia in type 2B and is therefore contraindicated.
For the classification of subtypes E2A-PBX1 and T-ALL, MDR has perfect averages in all measures.
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Adequate classification of subtype A and CRF02_AG pol sequences seems particularly challenging because of the overall high genetic variability within these subtypes.
In the long-term substudy, skin was classified as dry (eleven subjects [50%]), combination (six subjects [27%]), or normal (five subjects [23%]), with a skin phototype (Cesarini's classification) of subtype II or IV (nine subjects each [41%]), subtype III (three subjects [13%]), or subtype V (one subject [5%]).
Published metagene signatures were used: to determine molecular classification of subtype (Sorlie et al, 2001); to measure hypoxia (Winter et al, 2007; Buffa et al, 2010); for proliferation, invasion and immune response scores (Desmedt et al, 2008); and for ErBB2 scores (genes in common between (Desmedt et al, 2008) and (Wirapati et al, 2008)).
The tumours of origin were classified into molecular subtypes according to recent classification of MB subtypes [ 49– 51].
Our prior studies of cancer registry classification of lymphoma subtypes suggest good reliability for some subtypes (e.g., DLBCL, follicular lymphoma) (Clarke et al, 2004).
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