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The study patients were followed for 1 year to assess the presence and classification of leprosy reactions.
The presence of signs suggestive of leprosy and the operational classification of leprosy cases were associated with anti-PGL-I seropositivity.
The slit skin smear is among the most widely used supplementary assessments to confirm this diagnosis and to determine the operational classification of leprosy.
Our data provide evidence that all of the antigens tested are relevant tools to support the operational classification of leprosy and can also be used to identify individuals infected with M. leprae.
Later in 1971, he was appointed by WHO as the Director of the Cooperative Committee for the Study and Histologic Classification of Leprosy, and in 1973 was appointed Director of the Pan American Center for Research and Training in Leprosy and Tropical Diseases (WHO/PAHO).
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The association between anti-PGL-I seropositivity and the operational classification of the index leprosy case based on the multivariate analysis was also observed by other authors who performed multivariate analysis [ 13, 17].
The analyses of the relationship between anti-PGL-I seropositivity and the clinical characteristics of the index leprosy cases are shown in Table 3.> -wrap-foot> Pratiovalence ratio, 95%CI95%95 % confidence interval The seropositivity was analyzed according to the operational classification of the index leprosy case.
Several studies have identified that anti-PGL-I responses and the ML Flow rapid test can help in the classification of MB and PB leprosy patients to orient the choice of treatment [ 6, 8, 32, 33].
The variables associated with the differences in seropositivity in the study population were the presence of signs suggestive of leprosy, the operational leprosy classification and the degree of disability of the index case.
The factors associated with the variation of anti-PGL-I seropositivity among the study population were the presence of signs suggestive of leprosy (PR = 3.68; 95 % CI: 1.56 8.71), the operational leprosy classification (PR = 2.17; 95 % CI: 1.22 3.86) and grade 1 (PR = 1.83; 95 % CI: 1.02 3.26) or grade 2 disability (PR = 2.42; 95 % CI: 1.02 5.47) of the index leprosy case.
Two years later he died of leprosy.
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