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However, the central nervous system (CNS) has also been classically recognized as occupying a privileged site with respect to immune-related phenomena.
Although not classically recognized as an intracellular pathogen, uropathogenic E. coli exhibit enhanced macrophage survival relative to non-pathogenic strains, which may facilitate intracellular persistence.
This is because AD is classically recognized as a disease of memory, and indeed memory-related brain regions have long been known to be affected in the course of disease (Walsh et al, 2002; Chhatwal & Sperling, 2012).
Although classically recognized as a marker of differentiation [ 40, 45], CD26 expression has recently been reported to define a metastatic subpopulation of CICs within CRC and associated with development of metastasis in CRC patients [ 14, 21].
However, although classically recognized as a component of the methionine biosynthesis pathway, recombinant MetC from wBm was recently shown to have in vitro non-canonical L-alanine racemase activity [ 83] and likely has a role in peptidoglycan synthesis in Wolbachia.
The only other high loading of Factor 2 is on the Profiling Elements of Prosodic Systems Child version focus output test, which involves control of prosody in speech production, but is not classically recognized as a phonological skill in the same sense as the other four variables.
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Bile acids are cholesterol-derived surfactants that circulate actively between the liver and ileum and that are classically recognized for emulsifying dietary lipids to facilitate absorption.
The classically recognized functions of the renin-angiotensin system are mediated by type 1 (angiotensinensin receptors.
Wayne Martin, for instance, sees it as no more than a strategy for capturing a limited set of traditionally warranted inferences "by systematically translating or transposing the classically recognized forms".
Hence, three types of DR are classically recognized [ 11].
Recent observations have expanded the spectrum of prion diseases beyond the classically recognized forms.
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