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Liver is an important non classical target for estrogens, in addition to the classic estrogenic response of reproductive organs [ 40], and is implicated in non diabetic endocrine disorders [ 41].
These include the more selective delivery and/or activation of cisplatin-related prodrugs and the discovery of new non-covalent interactions with the classical target, DNA.
Remark 1 Classical target tracking also uses a gating step to exclude very unlikely measurement to the track assignments.
The way to process raw measurement of sensor in TBD is different from the classical target tracking methods.
They show significant differences to classical target classes and have been regarded as "undruggable" for a long time.
Obviously, ML is used to solve the classical target detection which belongs to the field of supervised learning whose labels can be known.
Similar(23)
This number is significantly larger than the number of single proteins, which are the classical targets for pharmacological intervention.
Method validation is however often omitted in plant metabolome studies, as the well-established methodologies for classical targeted analyses such as recovery optimization cannot be strictly applied.
The scope of the UPR-derived transcriptional signals goes beyond the classical targets.
Additionally, many cancers, including leukemias and colon cancers, are associated with reactivation of Hox genes, the classical targets of polycomb silencing [18], [19].
The false-discovery rate (FDR) during this annotation is controlled by the targeted data analysis conceptually derived from SRM using a classical target-decoy searching strategy [14,23].
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