Sentence examples for classical hallmarks from inspiring English sources

In neuroblastoma MYCN amplification (MYCNA) is associated with the classical hallmarks of tumor progression and metastasis, such as adhesion, motility and tissue invasion [29].

In contrast to X elements, the Y' elements also lack the classical hallmarks of heterochromatin, such as high Sir3 and Rap1 occupancy as well as low levels of histone H4 lysine 16 acetylation.

Indeed, conditional PS1 and PS2 knockout mice have been characterized by classical hallmarks of AD neuropathology including tau hyperphosphorylation, progressive neurodegeneration, impairment of synaptic plasticity and memory loss, all in the absence of Aβ [36], [37].

While the molecular mechanisms underlying the process of reprogramming remain obscure, recent reports indicate that classical hallmarks of malignancy such as inactivation of the p53 pathway [8] [10] or silencing of the ink4/arf locus [11] leading to immortalization [12] are shared between somatic cell reprogramming and cell transformation.

PE5-treated cells display classical hallmarks of apoptosis.

Taken together, 4-HNE-positive inclusions thus exhibit the classical hallmarks of aggresomes.

One animal had occasional multinucelated giant cells, the classical hallmark of SIV encephalitis (SIVE).

Aneuploidy, another classical hallmark of cancer cells, is also believed to be involved in tumorigenesis [ 12].

36– 38 Although rare in medulloblastoma, the presence of metastasis at diagnosis, particularly in the neural axis, is a classical hallmark of poor survival.

Moreover, Lewy bodies (a classical hallmark of Parkinson's disease) and peripheral inflammatory cells have been reported in dopamine-cell brain implants [ 42].

Aged microglia have been demonstrated to display an amoeboid morphology in particular when associated with Aβ plaques [ 14], a classical hallmark of AD pathology.