Sentence examples for classical dose from inspiring English sources

Moreover, the classical dose escalation rules (i.e. Fibonacci escalation, 3+3 design, dose-effect and dose-toxicity relationships) may not be suitable for MTA phase 1 trials.

As other similar studies [ 23, 25, 28, 30], the classical dose of tamoxifen (20 mg/day) is enough to reach steady state after 14 days of short-term treatment.

For instance, gemcitabine's dramatic toxicity when combined with radiation in early trials would have been detected by appropriate preclinical experiments and a classical dose escalation phase I methodology (Scalliet et al, 1998).

In order to further characterize KAE609, the most promising of this new class of antimalarials, a classical dose fractionation approach was adopted to identify the PK-PD index that correlates best with a reduction in parasitemia in the P. berghei malaria murine model.

The antiviral activity of peg-ArgI displayed a classical dose-response curve with IC50's in the sub-nanomolar range.

Both dose-finding designs substantially reduced the expected number of pregnancies to less than 4 pregnancies compared to 16.9 in the classical dose-finding design.

Tremelimumab was tested in a classical dose-escalating phase I trial [39].

As expected, Dex exhibited a classical dose-dependent inhibition of T-cell proliferation.

Vessels that did not conform to classical dose-response curves were not included in the analysis.

Although we might have expected increased classical dose-response curves, we found also that uranium contamination elicited U-shaped or inverted U-shaped curves.

Using flow cytometry, PSC833 doses responses curves obtained by analysing modal single cell fluorescence concentration (FL1-FC) confirmed the EC50 values obtained with the classical doses responses curve.