Clinical research looks for the classical psychopathological disorders (depression, anxiety disorders, stress, psychological trauma etc).
Cases of classical conversion disorder, such as those frequently described by 19th-century clinicians, have become rare.
Classical 'autistic disorder' (AD) falls under the ASD umbrella and, in addition to the three core symptoms, is frequently accompanied by mental retardation, as indicated by an intelligence quotient (IQ) of <70 [2]–[11].
Additional diseases beyond the classical congenital disorder of glycosylation are now thought to exist [ 41].
Duchenne muscular dystrophy (DMD) is a classical monogenic disorder, a model disease for genomic studies and a priority candidate for regenerative medicine and gene therapy.
Hypercholesterolemia also showed a significant but weaker association, even though obese individuals in our sample presented the classical lipid disorder of hypertriglyceridemia and low HDL cholesterol [ 34].
It makes sense to conceptually reserve the term 'mutation' for rare variants with a particularly high penetrance, usually associated with a detrimental phenotype, such as a classical monogenic disorder (e.g., sickle cell disease or haemophilia).
The activity of such inputs may drive changes in the PVN/SON VP and OT signature associated with a number of neuroendocrinological disturbances [314], and contribute to the dysregulation of the HPA axis implicated in many conditions including the classical psychosomatic disorders, cardiovascular disease, diabetes and affective disorders such as depression.
It is reputed that in the decades after the war, psychoanalysts began to report that there were fewer clients suffering from the classical Freudian disorders.
Mitochondrial encephalopathy and stroke-like episodes (MELAS) or Leber hereditary optic neuropathy (LHON) are classical mitochondrial disorders with characteristic phenotypes.
