Lack of statistical robustness is a classical difficulty when inferring tree with short sequences, and this is particularly true of homeodomain sequences (only 60 amino-acids).
Certain of classical music's difficulties are self-created: ossified concert norms, brain-dead programming, a pervasive fear of the new.
These scenarios, in their classical setups, have difficulties in handling multi-center data, as the training phase requires accessing the entire dataset.
For psychologists, the main problem has been that the classical theory has difficulty explaining a robust set of empirical findings.
Classical economists had difficulty explaining involuntary unemployment and recessions because they applied Say's Law to the labor market and expected that all those willing to work at the prevailing wage would be employed.
Cattle experimentally infected by intracerebral inoculation with L-type or H-type BSE present with two clinical phenotypes, either dull or nervous forms, which may be less clinically overt than classical BSE although difficulty in rising is consistently displayed.
Frege showed how to resolve these difficulties for classical logic in one fell swoop.
However, traditional numerical methods derived from classical continuum mechanics have difficulties in resolving discontinuous problems like ice damage.
These techniques overcome the difficulties of classical statistical methods such as spatial correlation, non-linearity of data, and overfitting (Were et al. 2015).
