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DWI has also been reported to be useful in detecting relapse of embryonal tumours such as medulloblastoma, being more sensitive than contrast-enhanced MRI in subjects with the classic variant [49].
The classic variant mainly affects elderly men of Eastern European Jewish and Mediterranean origin.
The classic variant has pale, finely granular cytoplasm while the eosinophilic variant has granular eosinophilic cytoplasm [ 201].
The classic variant of CSC consists of a shallow neuroretinal detachment located at the posterior pole of the ocular fundus.
Here we investigate combining classic variant filtering techniques with a knowledge-based approach that utilizes data from multiple sources to prioritize variants.
A section of thyroid papillary carcinoma, classic variant, previously proven to be OPN positive by Western blot, was used as positive control.
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All six ependymomas with mutations were classic variants from around the spinal cord.
Aberrations suggesting isochromosome 17q were present in eight (26%) medulloblastomas, of which seven were classic variants.
There is no difference in chromosomal loss pattern between eosinophilic and classic variants of chRCC [ 189].
Five cases (10.9%) were identified as RET/PTC1, and the other three (6.5%) as RET/PTC3 – both classic variants of PTC.
MiR-222 and miR-146b have been shown to be up-regulated at least 10-fold in classic variants of PTC compared with normal thyroid tissue [ 25].
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