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Intravitreal administration of clindamycin has advantages over classic therapy due to its reduced side effect profile.
Some use it as part of a quadruple therapy in immunocompetent patients, which consists of classic therapy plus oral clindamycin [5].
It has been shown that intravitreal clindamycin plus dexamethasone has similar outcomes to classic therapy (pyrimethamine, sulfadiazine, and prednisolone) for Toxoplasma retinochoroiditis in terms of the ability to reduce lesion size and vitreal inflammation as well as improve visual acuity [3, 4].
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It focuses on discovering, developing and commercializing novel pharmaceutical products, which are used in classic therapies.
Classic therapy-related myeloid leukemia typically occurs 5 to 7 years after exposure to alkylating agents and/or irradiation, has a myelodysplastic phase with trilineage involvement, and is characterized by abnormalities of the long arms of chromosomes 5 and/or 7. Response to treatment is poor, and allogenic bone marrow transplantation is recommended.
These applications facilitate targeting the antiapoptotic genes' products to kill cancer cell either alone or in combination with classic therapies.
Active vitamin D receptor activators (VDRA) are one of the classic therapies suggested to achieve those PTH targets [ 6].
In recent years, a variety of newly developed targeted anti-cancer therapies have successfully been combined with classic therapies, including the combination of EGFR-inhibition and radiotherapy in HNSCC [ 2].
Such therapies can include classic antifungal therapies including catheter lock therapies, combination therapies, natural compounds (Sardi et al. 2013) and immunotherapies that are gaining more and more attention.
In its early benefit assessments of SOF and SMV, German Federal Joint Committee defined both classic dual therapy (PR) and triple therapy with first generation PIs (Boceprevir or Telaprevir) as appropriate comparators.
Besides these so-called classic naturopathic therapies, homeopathy, manual therapy and acupuncture are commonly used CAM therapies [ 2].
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