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Further analysis revealed two major classes of variants or isomiRs(Table S10).
In the present study, the identified SGIV miRNAs exhibit sequence variations frequently, and two classes of variants that comprised of 5' and 3' terminal variability were found, as with iso-miR [27], [50].
For other classes of variants, pathogenicity scores were assigned as previously described (Robinson et al., 2014).
If that is correct, we might expect similarities in the functional enrichment patterns of these two classes of variants.
Since SNPs are more reliably called than other classes of variants, they are less likely to constitute noise.
Statistical models can also be used to assess whether there is enrichment of certain functional classes of variants genome wide.
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Independent validation of all classes of variant calls has demonstrated that they are of high quality.
The results of this analysis suggest that some classes of variant may confer an intermediate risk.
There are three classes of variant that we cannot be certain we have excluded from association.
Two classes of variant loxP sites are available to engineer stable Cre- loxP integrative recombination.
There are six different classes of variant present in HGMD (Figs. 1, 2).
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