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Consequently, there is transcriptional up-regulation of specific chaperones, transcription factors, and a regulated interruption of some classes of translation.
An interesting observation was that apart from metabolism, most of the noncanonical genes belonged to the functional classes of translation, posttranslational modifications, transcription, and signaling suggesting the occurrence of new, yet undiscovered immune response pathways.
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The eIF4E-binding proteins (4E-BPs) represent a diverse class of translation inhibitors that are often deregulated in cancer cells.
This novel class of translation inhibitors can properly be regarded as a promising starting point for the development of novel antibacterial therapeutic or screening tools.
6, we prove the same result for the class of translation algebras associated to locally finite extended metric spaces.
Overall for the class of translation complexes the pattern of activation of the response reflects closely the corresponding HL distributions [ 20] (eIF and eRF have short HL, eEF has not).
Group II of table 1 indicates that the class of "translation, ribosomal structure and biogenesis" which is responsible for the synthesis of ribosomal proteins was upregulated after 20 minutes.
Then the class of all translation networks with (G) as the activation function is dense in (X^p).
In addition, ORF length appears as a strong determinant of ribosome occupancy in this class and thus of translation efficiency (potentially due to the lack of post-transcriptional regulation, see Additional file 1: Figure S11) [ 32].
Moreover, we found that certain classes of RBPs or translation factors were associated with particular phenotypes, suggesting that specific points of mRNA regulation may influence distinct dendrite morphogenetic processes.
The anticipated scientific advances in understanding MOAs for classes of chemicals will require translation into dose response models for chemical risk assessments.
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