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We have three classes of reagent: primary RTK inhibitors, growth factor ligands, and secondary RTK inhibitors.
Application of tyrosinase, which is sensitive to some classes of reagent only, can also reduce the problem of many interfering compounds in biological systems, for example ascorbic acid (AA), uric acid (UA), and other neurotransmitters.
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In order to directly compare substrate and ABP imaging agents, we evaluated both classes of reagents in a simple xenograft mouse model of cancer.
A third class of reagent designed to covalently attach to peptides utilizing carbene insertion chemistry is also presented.
Here, we report a new class of reagents based on transcription activator-like effector nucleases (TALENs) to disrupt myostatin expression at the genome level.
Engineered binding proteins derived from non-antibody scaffolds constitute an increasingly prominent class of reagents in both research and therapeutic applications.
These results suggest that thiacycloheptynes constitute a promising class of reagents for Cu-free click chemistry.
In conclusion, thiacycloheptynes are a promising new class of reagents for bioorthogonal Cu-free click chemistry.
Among this class of reagents are several monoclonal antibody-anti CD3 scFv fusion reagents, some of which have undergone clinical evaluation with strong evidence of efficacy [ 14– 17].
Representative members of different classes of bifunctional reagents were taken into consideration, including bikethoxal and phenyl-diglyoxal [bis- 1,2-dicarbonyls)], cisplatin (coordinative binding agents), chlorambucil and nitrogen mustard [bis- 1,2-dicarbonylsmines], and sym-triazine trichloride (triazines).
After surveying different classes of organozinc reagents, the authors found that diorganozinc compounds are optimal for reactions with oxaziridine 16 to give a variety of N-Boc-protected primary amines (eq 25).
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