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IL-1β is a central orchestrator of immunity against various classes of pathogens [25] [31], and a key trigger of inflammatory diseases [32].
Toll-like receptors (TLRs) are a group of highly conserved molecules that allow the immune system to sense molecules that are present in most classes of pathogens.
Such specificity contrasts the long-held view that invertebrate innate immunity depends on a broad-spectrum recognition system, only capable of responding very generally to different classes of pathogens [2].
In the other classes of pathogens, no differences were observed.
The reduction was consistently observed for all principal classes of pathogens, including MDROs.
While this protection is nonspecific, several studies demonstrated that these effects enable discrimination between different classes of pathogens.
Similar(37)
Two functionally distinct classes of pathogen molecules are known to elicit plant immune responses [ 1- 3].
The use of host genomic markers offers an option to differentiate classes of pathogen exposure, gauge severity of impending illness and apply appropriate therapeutic strategies.
Amongst the canonical classes of pathogen effector molecules, many appear to be non-existent in the A. candida genome or represent significantly smaller classes of genes.
Although the function of the other LysM domain-containing receptor-like kinases is unknown, it is tempting to speculate that plants possess multiple receptor proteins for the perception of particular classes of pathogen-derived oligosaccharides.
Hundreds of AMPs have been discovered with overlapping activity spectra against different classes of pathogen (including viruses, bacteria and fungi), and this makes them attractive candidates for the development of novel antimicrobials.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com