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There are several classes of oral drugs used to control blood glucose levels, including sulfonylureas, biguanides, and thiazolidinediones.
Like current therapy, the new treatments involve use of two classes of oral and injected antibiotics.
Among the different classes of oral hypoglycemic agents, recent studies highlighted the distinguished mechanisms of sodium glucose transporter 2 blockers and dipeptidyl peptidase-4 inhibitors that settle their renoprotective actions beyond the hypoglycemic effects.
The aims were to determine the prevalence of severe hypoglycemic events and investigate associations among severe hypoglycemic and specific antidiabetic treatments (classes of oral agents and types of insulin analogs) in a large sample of nursing home patients with diabetes according to dementia status.
The development of three major classes of oral drugs that treat HIV and HCV infections and the growing evidence that novel, difficult targets can be accessed has prompted research into understanding design of drugs displaying cell permeability, solubility and ultimately oral bioavailability in bRo5 space.
Additionally, the available evidence that combinations of different classes of oral agents are more effective to lower glucose than maximal doses of a single drug, lead to recommend early or even initial prescription of combined therapies for the treatment of people with T2DM [8–12].
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Idris, I. & Donnelly, R. Dipeptidyl peptidase-IV inhibitors: a major new class of oral antidiabetic drug.
Thiazolidinediones (TZDs) are currently the most efficacious class of oral antidiabetics.
The biguanides are a class of oral hypoglycemic agents that are commonly used in the treatment of diabetes mellitus.
The development of ximelagatran provided the proof of principle that a specific oral thrombin inhibitor is safe and effective in a variety of thrombotic disorders, setting the stage for the introduction of a new class of oral thrombin and factor Xa inhibitors.
The company's proprietary drugs, known as "rycals," are a new class of oral agents that act on ryanodine receptors to repair the calcium leak associated with chronic diseases.
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