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No significant difference was apparent between these three classes of modification with regard to cloning efficiency, pregnancy and delivery rate.
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By using explicit chemistry to represent modified regions we can search across classes of modifications for common features.
We chose antibodies that represent the different classes of modifications present on the array (lysine and arginine methylation, phosphorylation, and acetylation).
In this context, the proteins and domains that recognize histone modifications, named "effectors" or "readers", are thought to define the functional consequences of many classes of modifications by transducing molecular events at chromatin into biological outcomes.
As lysine methylation does not change the side-chain charge, this class of modification exerts its biochemical effects predominantly by serving as a docking platform for protein protein interactions.
This finding suggests a mix-and-match evolutionary pattern for post-translationally modified peptide biosynthesis and export systems, in which similarity in the leader peptide region provides only indirect evidence of which class of modification (thiazole/oxazole versus lanthionine) will occur.
Of the three classes of epigenetic modifications, posttranslational modification of histone proteins undoubtedly is the most complex.
Rice genome possesses multiple genes encoding different classes of histone modification enzymes.
Where previous reviews have been structured around specific classes of surface modification, e.g. self-assembly, or have broadly examined the response of various cells to numerous surfaces, we aim in this article to focus in particular on the tissues involved in the nervous system whilst providing a broad overview of key issues from the field of cell and protein surface interactions with surfaces.
The effects of these classes of genetic modification on outcome are summarized in Table 4.
There is considerable interplay between different classes of epigenetic modification, but the mechanisms of interaction are poorly understood, and the hierarchical order of epigenetic alterations during unscheduled gene silencing in cancer is unknown.
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