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Two classes of derivatives of quinoline-8-ol; Mannich adducts of 5-chloroquinolin-8-ol and quinolin-8-yl carbamates were discovered to reactivate HIV-1 expression without causing T cell activation using a high-throughput system (HTS 77.
Records of all cleared and OTC trades across all the big classes of derivatives will be collected and stored in so-called "swap-data repositories", so the chances of anyone building up a big undisclosed position should be sharply reduced.
A panel of 39 simple aromatic and heterocyclic sulfonamides, as well as clinically used drugs incorporating sulfonamide/sulfamate zinc-binding groups, was used to investigate the inhibition profile of FtuβCA with these classes of derivatives.
That register shall contain the eligible classes of derivatives and the CCPs authorised to clear them.
(d) the classes of derivatives identified by ESMA in accordance with Article 4 5).
(11) Ensuring that the clearing obligation reduces systemic risk requires a process of identification of eligible classes of derivatives that should be subject to that obligation.
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Experimental NMR observations and computational experiments allowed the discovery of a new class of derivatives.
The optimization of this class of derivatives had provided us a start point to develop new anti-hepatic gluconeogenesis agents.
The bioassays indicated the first class of derivatives represented by 4f (LASSBio-693) and 4j (LASSBio-743), which were active in inhibiting the platelet aggregation induced by thrombin.
In order to further explore the main structure activity relationships of this class of derivatives we herein report the design, synthesis and biological evaluation of new analogues.
The different mechanisms of inhibition by these tested compounds as compared to sulfonamides, and their diverse inhibition profile for these mammalian isozymes, makes this class of derivatives of great interest for the design of novel CA inhibitors.
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