Exact(4)
During the double-blind treatment phase, the classes of concomitant medications used in at least 50%% of overall subjects were cardiovascular system (75.0 %), alimentary tract and metabolism (71.4 %), and respiratory system (57.1 %).
During the open-label treatment phase, the classes of concomitant medications used in at least 50%% of subjects were cardiovascular system (84.6 %), alimentary tract and metabolism (73.1 %), respiratory system (73.1 %), nervous system (61.5 %), anti-infectives for systemic use (57.7 %), blood and blood-forming organs (53.8 %), and musculoskeletal system (53.8 %).
Most other therapeutic classes of concomitant medication were permitted.
Such association became statistically significant for patients taking three classes of respiratory medications in addition to tiotropium (OR=1.96, 95% CI 1.06 to 3.61), with a peak in case of at least four classes of concomitant respiratory medications (adjusted OR=4.62, 95% CI 2.46 to 8.69).
Similar(54)
In LCA, concomitant variables are covariates considered in the process of formation of the latent classes, by the multinomial regression of latent classes on concomitant variables, to allow for different contributions of the items to define the classes for different levels of concomitants.
Persistent patients had lower counts of concomitant diabetes medication classes than non-persistent patients (measure 1: 0.86 versus 1.05 classes, p < 0.0001; measure 2: 0.94 versus 1.07 classes, p < 0.0001).
Additionally, to remove confounding factors due to the effects of other hemostat classes, concomitant use of non-ORC/non-OAH adjunctive hemostats were matched to isolate differences in outcomes between ORC and OAH classes.
The inclusion of concomitant variables helped to refine class 3 (reclassifying individuals from class 3 to class 2, thus decreasing the false-negatives).
We show that Smo modulators can uncouple the Smo-Ampk axis from canonical signaling and identify cyclopamine as one of a new class of "selective partial agonists," capable of concomitant inhibition of canonical and activation of noncanonical hedgehog signaling.
To assess the role of concomitant variable latent class models in the diagnosis of HF.
This class of enzymes catalyzes concomitant chlorination and peroxidation reactions and is involved in oxidative stress responses [ 212] and secondary metabolism [ 213].
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