Other classes of alterations including mutations and post-translational modifications occur less frequently (Whang et al, 1998; Verhagen et al, 2006; Yoshimoto et al, 2007, 2008).
While there are no significant changes for the levels of most classes of phospholipids, alterations in the individual levels of certain phospholipid species were observed (Figure S1).
We then created frequency-based classes of genomic alterations in DCIS and classes of differential frequencies between cases that progressed to IBC and controls that did not.
An evaluation of all classes of genomic alterations was performed, including base substitutions, short insertions/deletions, focal amplifications, homozygous deletions, and gene fusions/rearrangements, as previously described 3.
Each of these classes of microcirculatory alterations is associated with a reduced functional capillary density (FCD) and thereby a loss of the capacity of the microcirculation to transport oxygen to the tissues.
Finally, we wanted to design an approach that was suitable for exploring different classes of copy-number alteration.
For this outcome, death by UM metastases, disease-specific survival curves for each of the four classes of chromosome 3 alteration (D3, M3, AI, and partial M3) are shown in Figure 1.
Gene fusions represent an important class of somatic alterations in cancer.
The emergence of deep sequencing of the transcriptome has opened many opportunities for the identification of this class of genomic alterations, leading to the discovery of novel chimeric transcripts in cancers.
The emergence of deep sequencing of transcriptome, known as RNA-seq, has opened many opportunities for the identification of this class of genomic alterations, leading to the discovery of novel chimeric transcripts in many cancers [ 2].
