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Longerich, S., Basu, U., Alt, F. & Storb, U. AID in somatic hypermutation and class switch recombination.
Third, AID associates with the immunoglobulin-gene region in B cells undergoing class switch recombination10.
Guikema, J. E. et al. p53 represses class switch recombination to IgG2a through its antioxidant function.
Jegerlehner, A. et al. TLR9 signaling in B cells determines class switch recombination to IgG2a.
Stavnezer, J., Guikema, J. E. & Schrader, C. E. Mechanism and regulation of class switch recombination.
Lumsden, J. M. et al. Immunoglobulin class switch recombination is impaired in Atm-deficient mice.
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Figure 2 shows the mRNA expression levels of IgG4-specific class switch-related molecules in PBMCs and LSGs.
Figure 3 displays the mRNA expression levels of IgG4-nonspecific class switch-related molecules in PBMCs and LSGs.
This study showed different expression levels of IgG4 class switch-related molecules in LSGs than in PBMCs of IgG4-RD.
IgG4-nonspecific class switch-related molecules, such as CD40, CD154, BAFF, APRIL, IRF4, and AID also were examined.
For patients who are initially given an SSRI antidepressant, switch options include a within-class switch to a second SSRI, or an across-class switch to a medication with a different mechanism of action.
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