Most of CONSORT is also relevant to a wider class of trial designs, such as non-inferiority, equivalence, factorial, cluster, and crossover trials.
The pattern distinctness generalizes the Mahalanobis distance to an arbitrary number of classes, but also the case where there are no classes of trials because the design is described by parametric regressors.
Here I show that the most common methods of calculating classification images by averaging stimulus noise samples within stimulus-response classes of trials are much more general than has previously been demonstrated, and that they give unbiased estimates of an observer's template for a wide range of decision rules and non-Gaussian stimulus noise distributions.
Classes of trials with fewer discrepancies have found progressively smaller effect sizes, culminating in discrepancy-free trials reporting an effect size of zero Cite this as: BMJ 2014 348 g2688.
The serious bleeding event rate associated with drotrecogin alfa (activated) was similar across classes of trials (controlled, open-label, and compassionate-use; Table 3).
To account for these differences, we constructed a statistical methodology that models the existence of multiple classes of trials (among those testing the same combination) with different values of p (Additional file 2).
Studies reporting donation of study medication or receipt of financial support from a pharmaceutical company, and trials with one or more authors employed by the company manufacturing the test drug should be assigned to a separate class of industry-supported trials.
Ghose et al. studied computed physicochemical properties [atom-based logP (AlogP), atom-based molar refractivity (AMR), molecular mass, and the total number of atoms] in different classes of clinical-trial CNS compounds (depressant, psychotic, and hypnotic agents).
In other papers it was impossible to be sure what a priori objectives were from the published paper alone, but since methodological issues were discussed to greater depth in the non-drug trials, they are more likely to fall into Loscalzo's class of a priori pilot trials.
where K χ the number of trials for class χ (χ∈{L,R}).
