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They are a major class of targets of therapeutic intervention (Insel et al., 2007).
Members of a class of targets, in this case, categorical targets, are missed more often even though observers are looking for those targets.
Since medically relevant proteins often have a large number of evolutionarily related solved, holo protein structures that can serve as templates, they are a particularly good class of targets for the present methodology.
These findings demonstrate the therapeutic efficacy of CAR T cells directed against Tn-MUC1 and present aberrantly glycosylated antigens as a novel class of targets for tumor therapy with engineered T cells.
The MobyDick algorithm found approximately 300 motifs in each class of targets.
Thus it could have a substantially broader class of targets than PLA2s alone, and the target responsible for the effects we observed may not be a PLA2.
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Tyrosine kinases constitute an eligible class of target for novel drug discovery.
The affibody molecules are a promising class of targeting ligands with simple, robust, and precise structure and high affinity.
Cancer treatment has seen a new form of treatment in the form of a newer class of "targeted therapies," involving selective kinase inhibitors.
It is thought that two to three thousand different proteins are targeted to the chloroplast, and the 'transit peptides' that act as chloroplast targeting sequences are probably the largest class of targeting sequences in plants.
One promising class of targeting agents consists of the BH3 mimetics.
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