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If we include the class of mutation with no effect on phenotype, we have captured all possible mutational effects.
The spontaneous spectrum differed substantially from that of the radiation-induced spectrum for virtually every class of mutation.
Synonymous mutations might be expected to have no detectable effect on fitness, as this class of mutation does not change the amino-acid sequence of the encoded protein.
The major class of mutation on the Y is so rare that the ticks of the mutation clock are too many thousands of years apart to be reliably averaged.
"This class of mutation, changing G-C to A-T, accounts for about half of the 32,000 known pathogenic point mutations in humans". Both of the new tools are single-base editors, aimed at reversing these point mutations.
These results provide unequivocal evidence that synonymous mutations can drive adaptive evolution and suggest that this class of mutation may be underappreciated as a cause of adaptation and evolutionary dynamics.
Similar(23)
Richards, R.I. & Sutherland, G.R. Dynamic mutations: A new class of mutations causing human disease.
Well there is on important paper in 1971 as well for explaining the near neutral class of mutations.
The mutations discovered by Drs. Gharavi and Sanna-Cherchi and their colleagues belong to a class of mutations called copy number variations (CNVs).
A second class of mutations, exemplified by alterations in PKI, did not affect 40S binding but altered the positioning of the ribosome on the IRES, indicating that PKI is involved in the correct positioning of IRES-associated ribosomes.
A second class of mutations, exemplified by alterations in PKI, did not affect 40 S binding but altered the positioning of the ribosome on the IRES, indicating that PKI is involved in the correct positioning of IRES-associated ribosomes.
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