Sentence examples for class of mediators from inspiring English sources

The SDF-1α/CXCR4 axis belongs to this class of mediators and recent studies have shown that inhibition of CXCR4 with antibodies, peptide antagonists or siRNA all reduce metastasis in several solid tumors, including breast [8], [36], [37], [38], melanoma [12], [39], pancreas [40], prostate [41] and colon [42] cancers.

Late-phase preconditioning is different; it involves transcription factor activation leading to a new class of mediators.

A second class of mediators that affect insulin sensitivity in both muscle and liver and which are derived from adipose tissue are adipokines.

AnxA1 is the prototype of a new class of mediators able to potently modulate both the innate and adaptive immune response; while effecting inhibitory properties on inflammatory cells, setting in motion pro-resolving responses, this protein acts as a positive relay in T cell activation.

While it is certainly not uncommon to use only one IS in studies of multiple analytes [ 15, 21, 25], it would be preferable to use stable isotope-labeled standards for each analyte under investigation or to use one such labeled standard per class of mediators targeted [ 24].

The integrin VLA-4 is constitutively expressed in eosinophils [ 5], whereas Mac-1 is expressed in eosinophils stimulated with different class of mediators such as platelet-activating factor (PAF), granulocyte macrophage colony stimulating factor (GM-CSF), and N-formyl-methionyl-leucyl-phenylalanine (fMLP) [ 6- 8].

In addition, a new class of mediator families derived from fish oil the EPA -and DHA-derived resolvins (RvE1 and RvD1) and the DHA-derived protectin (PD1), which act locally, and possess potent anti-inflammatory novel bioactions have recently been indentified and may represent a potential mechanism for the therapeutic benefits derived from diets rich in these omega-3 essential fatty acids.

The results of this analysis indicate five classes of mediators capable of tuning the development of the interaction process according to the context and emotional state of the participants.

Because CC chemokines such as eotaxin and RANTES also play critical roles in this phenomenon, it would seem likely that members of both classes of mediators contribute to this response.

The principal aim was to establish the correlations which may exist among the different classes of mediators and aging with the hypothesis that the oral cavity may be in a state of low chronic inflammation.

Furthermore, the tight association between these two classes of mediators (OP-1 and IL-6) was documented under both experimental conditions (plus or minus OP-1).