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Rilonacept belongs to a class of biologics called "cytokine traps".
MiRs are emerging as a promising class of biologics pursued for their biomarker and future therapeutic potential in RT.
Specifically, such patients do not respond to a class of biologics targeting anti-epidermal growth factor receptor (EGFR) antibody therapy.
These agents were the first class of biologics approved by the Food and Drug Administration FDAA) for the treatment of RA.
Another class of biologics that promote chondrogenesis are the transcription factors sex-determining region Y-box 9 (SOX9) and related L-SOX5 and SOX6.
Abatacept is the first member of a new class of biologics which inhibit T-cell activation by binding to CD80/86 and modulating its interaction with CD28.
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However, adequate clinical responses were not obtained in any of the patients evaluated, regardless of the class of biologic used.
Another therapeutic option is to switch to a different class of biologic agent such as rituximab, tocilizumab or abatacept [ 4- 6].
Anti tumour necrosis factor alpha (anti-TNFα) therapy was the first class of biologic agent chosen in all six cases.
The first class of biologic drugs that came available were the TNFα-blockers infliximab, etanercept and adalimu-mab, and the recombinant human IL-1 receptor antagonist anakinra [ 7].
Abatacept is the first member of a new class of biologic agents for RA treatment that inhibits T-cell activation by binding to CD80/86, modulating its interaction with CD28.
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