It appears that at least three classes of interaction consistent with functional classes of attachment have been resolved (8).
Structural comparison of H and G glycoprotein β-propellers reveals, however, that, despite having common protein-binding capacities, these two classes of attachment glycoprotein are markedly different in both their architecture and mode of receptor engagement.
Thus, the lead formulations are likely a part of a new class of bacteria attachment resistant materials where the ester group combined with cyclic or aromatic hydrocarbon goups act together to resist bacterial attachment.
Both SARs and MARs show a bimodal distribution consistent with two ranges of loop sizes that may serve different functions as predicted by the interchromosomal network model that also proposes various classes of nuclear attachment (33).
Moreover, the initial attachment of metastatic cells to bone endothelial cells is largely attributed to the lectin class of protein adhesion molecules.
A considerable part (classes 2 and 3) maintained a continuously 'high level' of attachment, and about 12% (classes 5 and 7) displayed a 'strengthening' of attachment towards the end of the follow-up.
A key challenge for developing this class of probes lies in the point of attachment of the reporter group.
Due to the nonpersistent nature of this class of nerve agents, the covalent attachment ensures the integrity of the analyte as opposed to a non-covalent approach where the decomposition products of pinacolyl methyl phosphonate (PMP) can lead to a variety of binding cavities based upon the nature of the decomposed products.
A new class of material resistant to bacterial attachment has been discovered that is formed from polyacrylates with hydrocarbon pendant groups.
In summary, we report a new class of materials resistant to bacterial attachment discovered using a high throughput discovery methodology with up to 81%, 99% and 99% reduction in bacterial coverage for P aeruginosa, S. aureus and UPEC, respectively, compared to a market leading anti-bacterial silver hydrogel.
