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Examples of OPS/SDF movies of each class of abnormality can be viewed on our web site [ 43].
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In humans, 46,XY gonadal dysgenesis (46,XY GD) is characterized by abnormal testis determination and is an example of a wider class of abnormalities known as disorders of sex development (DSD).
Constructivists often, as we will see later, argue that disease judgments appeal to biological processes that are to be understood in terms of human practices rather than membership in some biologically definable class of abnormalities or malfunctions.
At the microcirculatory level, all classes of abnormalities seen during distributive shock show normal to hyperdynamic venular flow [ 8, 9].
Interestingly, the class V types of abnormality are also observed in extreme exercise.
The aim is to classify thirteen classes of thalassaemia abnormality and one control class by inspecting the distribution of multiple types of haemoglobin in blood specimens, which are identified via high performance liquid chromatography (HPLC).
This analysis identified two distinct classes of retinal abnormality in homozygous mutant animals.
Examples for building block ontologies that are used for the representation of classes of phenotypic abnormalities are given in the upper part of Table 1.
In Table 1, the diseases observed so far are listed next to the different classes of microcirculatory abnormalities seen in Figure 2.
Although the classes of capillary abnormalities we identified may be caused by different mechanisms, they all have in common a distributive defect caused by functional shunting of capillaries in the presence of normal or hyperdynamic venular flow.
From this perspective, it can be expected that the different classes of microcirculatry abnormalities shown in Figure 2 are caused by a combination of different regional pathogenic mechanisms while having a similar systemic hemodynamics profile.
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