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Moreover, the Pew Research Center now reports that the shrinking of the middle class is occurring just as rapidly in major metropolitan centers as it is in more troubled regions like Appalachia, the Deep South, and the Rust Belt.
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What hasn't been clear is why this geographic class sorting is occurring, whether it is compounding the effects of income inequality, and what it implies for cities trying to speed up growth.
First, much of the Ig class switching that is occurring during the early Ab response is induced during the extrafollicular phase — outside GCs.
World class research is world class research, whether it is occurring in a research-intensive university or in another other sort of university.
Rather, the mtDNA data are consistent with contemporary subspecies nomenclature and data from both marker classes suggest that gene flow is occurring at a relatively high level among these subspecies.
What puts the present period in a class by itself is that it is occurring when the nation is, by any normal standard, fundamentally safe, prosperous and at peace.
This is occurring while economy-class passengers are being burdened by baggage fees, poor food or no food or even water on some domestic flights, and extra fees for more legroom.
From a clinical perspective it would also appear that the varying B cell malignancies of acute undifferentiated leukemia all the way through to myeloma also retain their then current natural level of apoptotic potential associated with the unique genetic processes of; VDJ rearrangement, somatic hypermutation and class switching that were occurring at the time of malignant transformation [ 27].
Instruction, which used to happen in class, is now occurred at home with teacher-created videos and interactive lessons.
Seroconvertion of IgG-class anti-PF4/heparin antibodies were occurred in a significant number of patients receiving total joint arthroplasty (TKA and THA) treatments and their frequencies may depend on anti-thrombotic prophylaxis agents and types of operation (TKA or THA).
"That the middle [constitution] is best is evident, for it is the freest from faction: where the middle class is numerous, there least occur factions and divisions among citizens" (IV.11.1296a7 9).
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