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Serious infections were defined as any event in the Medical Dictionary for Regulatory Activities System-Organ Class "Infections and Infestations" that met the standard criteria for a SAE, including any infection reported as "serious" by the investigator and any infection that required hospitalization.
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Under the assumption that there are no correlations between features given the class (infection state) variable, NB derives a conditional probability for the relationships between the attribute values and the class.
A fuzzy logic program was created using 155 randomly selected patients' data with four input (demographic variables) and four output classes (infections with "staphylococci", "streptococci", "Escherichia coli" or "non-E. coli gram negative rods (non-E.coli GNR)").
β-Lactam antibiotics are the traditional antibiotic class for infections caused by Gram-negative bacteria [ 3].
Regarding AEs in the MedDRA system organ class of "infections and infestations," the study by Carbonell-Estrany et al found rates that were comparable for motavizumab and palivizumab.
The most common serious TEAE system organ class was infections and infestations (58/3357, 1.7%), most commonly pneumonia (0.27%), bacterial arthritis (0.15%), sepsis (0.12%) and tuberculosis (0.12%).
AE within the system organ class of infections and infestations were reported for 26%and32%2% of patients on placebo and ofatumumab, respectively.
Each line is the result of 10 SI (susceptible-infected) simulations using the centroid user/node of each outlier class as infection root.
In order to elucidate the role of each RNR class during infection, S. Typhimurium single and double RNR mutants (as well as Fur and NrdR mutants) were used in infection assays with macrophage and epithelial cell lines.
Class 1 (infection-negative) individuals are "true-negative" cases.
All events observed were divided into 9 classes regarding infections, cardiovascular events and malignancies.
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