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"It is very likely that there is some kind of class effect," Dr. Wolfe said.
The new data about Bextra "renders the evidence that this is a class effect overwhelming," he argued.
Instead, Pfizer insisted that Vioxx was unique and that there was no evidence of a class effect.
"I think one could only characterize their response to the Vioxx story, where they publicly dismissed the possibility of a class effect, as deceptive," Dr. FitzGerald said.
While Novo claims the thyroid cancer issue is a class effect, there is no credible evidence to support this claim.
Some ocular toxicities can be considered a class effect and a direct result of intervening with the MAPK pathway.
This suggests that these hydroxymethylglutaryl coenzyme A reductase inhibitors exhibit a "class effect" with respect to progression of subclinical atherosclerosis.
In summary, whilst the Fab region of the antibody determines its antigen specificity, the Fc region of the antibody determines the antibody's class effect.
Class effect: other JAK inhibitors contraindicated?
However, a significant vesicle class effect is found.
These studies identify sphinomyelinase-dependent generation of ceramide as a class effect of alkylphospholipids and PIAs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com